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Lonidamine
CAS No. 50264-69-2
Lonidamine( AF 1890 | DICA | Diclondazolic Acid )
Catalog No. M14699 CAS No. 50264-69-2
Lonidamine is an orally administered small molecule hexokinase inactivator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
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| 5MG | 41 | In Stock |
|
| 10MG | 52 | In Stock |
|
| 25MG | 68 | In Stock |
|
| 50MG | 105 | In Stock |
|
| 100MG | 137 | In Stock |
|
| 500MG | 336 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLonidamine
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NoteResearch use only, not for human use.
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Brief DescriptionLonidamine is an orally administered small molecule hexokinase inactivator.
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DescriptionLonidamine is an orally administered small molecule hexokinase inactivator.(In Vitro):Lonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.(In Vivo):Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.
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In VitroLonidamine (100 μM, 24 h) inhibits TGF-β-stimulated lactate production and oxygen consumption rate in AKR-2B and TIG-1 cells.Lonidamine (100 μM, 24/48 h) inhibits H2030BrM3 and A549 cell proliferation.Lonidamine (100-200 μM, 24 h) inhibits H2030BrM3 and A549 cell invasion.Lonidamine (100-1000 μM, 24 h) inhibits mitochondrial complex I and II activities.Lonidamine (200 μM, 24 h) increases ROS generation in H2030BrM3 lung cancer cells.
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In VivoLonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model. Animal Model:Lonidamine (oral administration, 10-100 mg/kg/day, d10 to d20) improves lung function by inhibiting hexokinase 2 (HK2) activity in BLM-induced pulmonary fibrosis murine model.Dosage:10, 30, 100 mg/kg/day Administration:Oral administration, daily, d10 to d20 after BLM treatment.Result:Partially or completely reversed the increases in HK2 and lactate induced by BLM and reduced the expression of 10 profibrotic mediators.
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SynonymsAF 1890 | DICA | Diclondazolic Acid
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PathwayOthers
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TargetOther Targets
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Recptorhexokinase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number50264-69-2
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Formula Weight321.17
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Molecular FormulaC15H10Cl2N2O2
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Purity>98% (HPLC)
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SolubilityDMSO: 64 mg/mL (199.27 mM)
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SMILESO=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)O
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Chemical Name1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Floridi A, et al. J Natl Y Inst, 1981, 66(3), 497-499.
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