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LolCDE-IN-1

CAS No. 1639933-78-0

LolCDE-IN-1( —— )

Catalog No. M21571 CAS No. 1639933-78-0

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex with antibacterial activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LolCDE-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex with antibacterial activity.
  • Description
    LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex with antibacterial activity.
  • In Vitro
    LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane.LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml.LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Bacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1639933-78-0
  • Formula Weight
    345.37
  • Molecular Formula
    C21H16FN3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (120.65 mM)
  • SMILES
    Fc1ccc(COc2cccc(c2)-c2n[nH]cc2-c2ccncc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Nayar AS et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.
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