LolCDE-IN-1( —— )

Catalog No. M21571 CAS No. 1639933-78-0

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex with antibacterial activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

LolCDE-IN-1
Note

Research use only, not for human use.
Brief Description

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex with antibacterial activity.
Description

LolCDE-IN-1 is an inhibitor of the Lol proteins (LolCDE) complex with antibacterial activity.
In Vitro

LolCDE-IN-1 (compound 2) inhibits the function of the LolCDE complex, which is required for transport of lipoproteins to the outer membrane.LolCDE-IN-1 inhibits E. coli ATCC 25922 and E. coli ATCC 25922 ΔtolCwith MIC with 8 μg/ml and 0.125 μg/ml.LolCDE-IN-1 inhibits bacterial growth by targeting LolCDE to block lipoprotein transport to the outer membrane.
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Bacterial
Research Area

——
Indication

——

Chemical Information

CAS Number

1639933-78-0
Formula Weight

345.37
Molecular Formula

C21H16FN3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 41.67 mg/mL (120.65 mM)
SMILES

Fc1ccc(COc2cccc(c2)-c2n[nH]cc2-c2ccncc2)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Nayar AS et al. Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay. J Bacteriol. 2015 May;197(10):1726-34.

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