Linderalactone( Linderalactone )

Catalog No. M19045 CAS No. 728-61-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Linderalactone
Note

Research use only, not for human use.
Brief Description

Linderalactone showed significant inhibitory effects on superoxide anion generation by human neutrophils in response to fMLP/CB, values of IC5 is 8.48 μg/mL.
Description

Linderalactone is an NSAID isolated from Lindera aggregata.
In Vitro

Cell Viability Assay Cell Line:Lung cancer A549 cells Concentration:0 μM, 1.6 μM, 3.2 μM, 6.25 μM, 12.5 μM, 25 μM, 50 μM, 100 μM Incubation Time:24 hours Result:Inhibited the growth of A549 cells concentration-dependently.Apoptosis Analysis Cell Line:Lung cancer A549 cells Concentration:7.5 μM, 15 μM, 30 μM Incubation Time:Result:Induced apoptosis in A549 cells in a dose-dependent manner. Cell Cycle Analysis Cell Line:Lung cancer A549 cells Concentration:7.5 μM, 15 μM, 30 μM Incubation Time:24 hours Result:Induced G2/M cell cycle arrest.Western Blot Analysis Cell Line:Lung cancer A549 cells Concentration:7.5 μM, 15 μM, 30 μM Incubation Time:Result:Inhibited the JAK/STAT pathway in A549 cells.
In Vivo

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Synonyms

Linderalactone
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Others-Field
Indication

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CAS Number

728-61-0
Formula Weight

244.29
Molecular Formula

C15H16O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 33.33 mg/mL (136.44 mM)
SMILES

CC1=CCCC2=CC(C3=C(C1)OC=C3C)OC2=O
Chemical Name

(R,7Z,10E)-3,11-dimethyl-4,8,9,12-tetrahydro-6H-4,7-(metheno)furo[3,2-c][1]oxacycloundecin-6-one