Lifirafenib
CAS No. 1446090-79-4
Lifirafenib ( Beigene-283; BGB-283 )
Catalog No. M23610 CAS No. 1446090-79-4
Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 95 | In Stock |
|
100MG | 827 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLifirafenib
-
NoteResearch use only, not for human use.
-
Brief DescriptionLifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
-
DescriptionLifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
-
SynonymsBeigene-283; BGB-283
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorB-Raf (V600E);EGFR;EGFR (L858R/T790M)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1446090-79-4
-
Formula Weight478.4
-
Molecular FormulaC25H17F3N4O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:100 mg/mL (209.02 mM)
-
SMILESO=C1Nc2nccc(Oc(cc3)cc(C45)c3OC4C5c3nc(ccc(C(F)(F)F)c4)c4[nH]3)c2CC1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Tang Z, et al. Mol Cancer Ther. 2015, 14(10):2187-97.
molnova catalog
related products
-
(E)-AG 556
AG 556 is a selective inhibitor of EGFR and blocks LPS-induced TNF-α production.
-
EGFR-IN-5
EGFR-IN-5 is a selective inhibitor of EGFR. The IC50s for EGFR, EGFR(L858R), EGFR(L858R/T790M), and EGFR(L858R/T790M/C797S) are 10.4, 1.1, 34, 7.2 nM, respectively.
-
Almonertinib mesylat...
Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer studies.