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Lificiguat

CAS No. 170632-47-0

Lificiguat ( YC1; YC 1; YC-1; Lificiguat )

Catalog No. M18115 CAS No. 170632-47-0

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 39 In Stock
10MG 55 In Stock
25MG 114 In Stock
50MG 227 In Stock
100MG 389 In Stock
200MG 575 In Stock
500MG 888 In Stock
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Biological Information

  • Product Name
    Lificiguat
  • Note
    Research use only, not for human use.
  • Brief Description
    YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
  • Description
    Lificiguat, also known as YC-1, is a inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). YC-1 is widely used as a potent inhibitor of HIF-1alpha both in vitro and in vivo, and is also being developed as a novel anticancer drug. YC-1 effectively inhibits tumor invasion and metastasis, and imply that YC-1 is worth while to further develop as a multipurpose anticancer drug.
  • Synonyms
    YC1; YC 1; YC-1; Lificiguat
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    sGC;HIF-1α
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    170632-47-0
  • Formula Weight
    304.34
  • Molecular Formula
    C19H16N2O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 51 mg/mL; 167.58 mM
  • SMILES
    OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
  • Chemical Name
    5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Martin E,etal.YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12938-42.
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