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Lificiguat

CAS No. 170632-47-0

Lificiguat ( YC1; YC 1; YC-1; Lificiguat )

Catalog No. M18115 CAS No. 170632-47-0

YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 39 In Stock
10MG 55 In Stock
25MG 114 In Stock
50MG 227 In Stock
100MG 389 In Stock
200MG 575 In Stock
500MG 888 In Stock
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Biological Information

  • Product Name
    Lificiguat
  • Note
    Research use only, not for human use.
  • Brief Description
    YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha).
  • Description
    Lificiguat, also known as YC-1, is a inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). YC-1 is widely used as a potent inhibitor of HIF-1alpha both in vitro and in vivo, and is also being developed as a novel anticancer drug. YC-1 effectively inhibits tumor invasion and metastasis, and imply that YC-1 is worth while to further develop as a multipurpose anticancer drug.
  • Synonyms
    YC1; YC 1; YC-1; Lificiguat
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    sGC;HIF-1α
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    170632-47-0
  • Formula Weight
    304.34
  • Molecular Formula
    C19H16N2O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 51 mg/mL; 167.58 mM
  • SMILES
    OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1
  • Chemical Name
    5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Martin E,etal.YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12938-42.
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