Liensinine

Research use only, not for human use.

Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.

Liensinine is a novel autophagy/mitophagy inhibitor.

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Animal Model:KM miceDosage:100 mg/kg, 200 mg/kg Administration:oral gavage, daily, 10 weeks Result:Reduced the gingival index and increased the SOD levels, the CAT, GSH-Px levels and decreased the NO, MDA, and ET levels compared to the control group.Animal Model:Institute of Cancer Research (ICR) mice (male, 20-22 g) Dosage:Administration:5 mg/kg by oral administration; 1 mg/kg by intravenous administration Result:The pharmacokinetic parameters of Liensinine in mice.

Liensinine |

Others

Other Targets

Others

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2586-96-1

610.75

C37H42N2O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (81.87 mM)

CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC

4-(((R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-2-(((R)-1-(4-hydroxybenzyl)-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)oxy)phenol

(-20℃)

With Ice Pack

≥ 2 years