Lidorestat

CAS No. 245116-90-9

Lidorestat( —— )

Catalog No. M33408 CAS No. 245116-90-9

Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 38 Get Quote
10MG 61 Get Quote
25MG 99 Get Quote
50MG 152 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Lidorestat
  • Note
    Research use only, not for human use.
  • Brief Description
    Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts.
  • Description
    Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.
  • In Vitro
    From in vitro experiments, Lidorestat has a reported IC50 against recombinant human aldose reductase (/h/-ALR2) of 5 μM. Against recombinant human aldehyde reductase (/h/-ALR1), Lidorestat has a reported IC50 of 27,000 μM, yielding a selectivity of /h/-ALR1//h/-ALR2 of 5400:1.
  • In Vivo
    Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight.Animal Model:Diabeticlow-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice Dosage:25 mg/kg/day Administration:Oral administration; twice daily; for 6 weeks Result: Diabetic hAR-expressing mice had decreased fructose and reduced mortality.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Reductase
  • Recptor
    Reductase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    245116-90-9
  • Formula Weight
    376.35
  • Molecular Formula
    C18H11F3N2O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (132.86 mM; Ultrasonic (<60°C)
  • SMILES
    OC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Noh HL, et al. Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat. J Pharmacol Exp Ther. 2009 Feb;328(2):496-503.?
molnova catalog
related products
  • CH5138303

    CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.

  • Sulindac sulfone

    Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).

  • MK 0434

    MK 0434 is an orally active steroidal 5 alpha-reductase inhibitor.