Licarbazepine

CAS No. 29331-92-8

Licarbazepine( Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer )

Catalog No. M21077 CAS No. 29331-92-8

Licarbazepine is the pharmacologically active metabolite of oxcarbazepine a drug indicated for the treatment of partial seizures and bipolar disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Licarbazepine
  • Note
    Research use only, not for human use.
  • Brief Description
    Licarbazepine is the pharmacologically active metabolite of oxcarbazepine a drug indicated for the treatment of partial seizures and bipolar disorders.
  • Description
    Licarbazepine is the pharmacologically active metabolite of oxcarbazepine a drug indicated for the treatment of partial seizures and bipolar disorders.(In Vivo):Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification.ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge. ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).
  • In Vitro
    ——
  • In Vivo
    Eslicarbazepine acetate (ESL) is an oral pro-drug that is rapidly and extensively metabolized by the liver via a hydrolytic first-pass metabolism into S-Licarbazepine, the biologically active drug. The plasma level of the prodrug remains below quantification. ESL is a potent antiepileptic agent with a spectrum of action essentially limited to partial-onset and generalized tonic-clonic seizures. Its main mechanism of action is by blocking the voltage-gated sodium channel. ESL works by blocking the voltage-gated sodium channel, which play an essential role in the generation and propagation of the epileptic discharge.?ESL is well absorbed after oral administration with a bio-availability about 16% higher than that observed after an equivalent dose of Oxcarbazepine (OXC).
  • Synonyms
    Licarbazepine | ?1011-hydroxy-1011 Dihydrocarbamezer
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Neurological Disease
  • Indication
    Bipolar Disorder

Chemical Information

  • CAS Number
    29331-92-8
  • Formula Weight
    254.28
  • Molecular Formula
    C15H14N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:3mg/ml(11.7mM)
  • SMILES
    NC(=O)N1c2ccccc2CC(O)c2ccccc21
  • Chemical Name
    10-hydroxy-1011-dihydro-5H-dibenzo[bf]azepine-5-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Begas E Tsakalof A Dardiotis E et al. Development and validation of a reversed-phase HPLC method for licarbazepine monitoring in serum of patients under oxcarbazepine treatment: HPLC method for licarbazepine monitoring in serum of patients[J]. Biomedical Chromatography 2017 31(9).
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