Levodropropizine( Levodropropizine | DF 526 | DF-526 | DF526 | Levotuss )

Catalog No. M16909 CAS No. 99291-25-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Levodropropizine
Note

Research use only, not for human use.
Brief Description

Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
Description

Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
In Vitro

——
In Vivo

Animal Model:Pentylenetetrazol (PTZ)-induced status epilepticus in rats Dosage:20 and 40 mg/kg Administration:i.p.Result:Decreased Mean electroencephalogram (EEG) spike wave percentage score from 76.8% (placebo) to 13.1% (lower dose) and 7.6% (higher dose).Decreased Racine's Convulsion Scale (RCS) from a mean of 5.8 (placebo) to 1.83 (lower dose) and 1.16 (higher dose). Increased time to first myoclonic jerk (TFMJ) from a mean of 65.1 s (placebo), to 247.3 s (lower dose) and 295.5 s (higher dose).
Synonyms

Levodropropizine | DF 526 | DF-526 | DF526 | Levotuss
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

HT
Research Area

Inflammation/Immunology
Indication

——

CAS Number

99291-25-5
Formula Weight

236.31
Molecular Formula

C13H20N2O2
Purity

>98% (HPLC)
Solubility

Ethanol: 47 mg/mL (198.89 mM); Water: 15 mg/mL (63.47 mM); DMSO: 47 mg/mL (198.89 mM)
SMILES

OC[C@@H](O)CN1CCN(C2=CC=CC=C2)CC1
Chemical Name

(S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol

1.Melillo G, et al. Arzneimittelforschung, 1988, 38(8), 1144-1150.

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