Leptomerine

Research use only, not for human use.

Leptomerine is an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae). Leptomerine shows as anticholinesterasic activity and can be used in Alzheimer Disease studies.

Leptomerine is an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae). Leptomerine shows as anticholinesterasic activity and can be used in Alzheimer Disease studies.(In Vitro):Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. The alkaloid Leptomerine showed the highest activity (IC50 = 2.5 mM), similar to that of the reference compound galanthamine (IC50 = 1.7 mM).

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Metabolic Enzyme/Protease

AChE

AChE

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22048-97-1

201.3

C13H15NO

>98% (HPLC)

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CCCc1cc(=O)c2ccccc2n1C

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(-20℃)

With Ice Pack

≥ 2 years