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Lenalidomide-OH
CAS No. 1416990-08-3
Lenalidomide-OH( —— )
Catalog No. M23571 CAS No. 1416990-08-3
Lenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 38 | In Stock |
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| 25MG | 61 | In Stock |
|
| 50MG | 88 | In Stock |
|
| 100MG | 132 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLenalidomide-OH
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NoteResearch use only, not for human use.
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Brief DescriptionLenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein.
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DescriptionLenalidomide-OH is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC BTK degrader SJF620.
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In VitroLenalidomide-OH can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
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In Vivo——
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Synonyms——
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PathwayPROTACs
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TargetPROTAC
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RecptorCereblon
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Research Area——
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Indication——
Chemical Information
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CAS Number1416990-08-3
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Formula Weight260.25
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Molecular FormulaC13H12N2O4
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Purity>98% (HPLC)
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SolubilityDMSO : 11 mg/mL (42.27 mM; Need ultrasonic)
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SMILESO=C(C(N(CC1=C2C=CC(O)=C1)C2=O)CC3)NC3=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877.
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