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Lats-IN-1
CAS No. 1424635-83-5
Lats-IN-1( —— )
Catalog No. M23576 CAS No. 1424635-83-5
Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 133 | In Stock |
|
| 10MG | 209 | In Stock |
|
| 25MG | 415 | In Stock |
|
| 50MG | 536 | In Stock |
|
| 100MG | 763 | In Stock |
|
| 200MG | 1053 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLats-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionLats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
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DescriptionLats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
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In VitroCell Proliferation Assay Cell Line:MCF 10A cells Concentration:10 μM Incubation Time:24 hours Result:Decreased the phosphorylation of Yap at residue S127.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorLats1|Lats2
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Research Area——
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Indication——
Chemical Information
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CAS Number1424635-83-5
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Formula Weight334.39
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Molecular FormulaC18H14N4OS
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Purity>98% (HPLC)
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SolubilityDMSO:83.33 mg/mL (249.20 mM; Need ultrasonic)
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SMILESO=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.
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