Lats-IN-1( —— )

Catalog No. M23576 CAS No. 1424635-83-5

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	209	In Stock
25MG	415	In Stock
50MG	536	In Stock
100MG	763	In Stock
200MG	1053	In Stock
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Biological Information

Product Name

Lats-IN-1
Note

Research use only, not for human use.
Brief Description

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
Description

Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.
In Vitro

Cell Proliferation Assay Cell Line:MCF 10A cells Concentration:10 μM Incubation Time:24 hours Result:Decreased the phosphorylation of Yap at residue S127.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Lats1|Lats2
Research Area

——
Indication

——

Chemical Information

CAS Number

1424635-83-5
Formula Weight

334.39
Molecular Formula

C18H14N4OS
Purity

>98% (HPLC)
Solubility

DMSO:83.33 mg/mL (249.20 mM; Need ultrasonic)
SMILES

O=C(C1=CNC2=NC=CC=C12)/N=C(SC=C3)/N3CC4=CC=CC=C4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Nathaniel Kastan, et al. Small-molecule inhibition of Lats kinases promotes Yap-dependent proliferation in postmitotic mammalian tissues. bioRxiv 2020.02.11.944157.

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