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Lasmiditan

CAS No. 439239-90-4

Lasmiditan( COL-144 | LY573144 )

Catalog No. M18554 CAS No. 439239-90-4

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 138 In Stock
10MG 239 In Stock
25MG 525 In Stock
50MG 957 In Stock
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Biological Information

  • Product Name
    Lasmiditan
  • Note
    Research use only, not for human use.
  • Brief Description
    Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.
  • Description
    Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    COL-144 | LY573144
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT1F
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    439239-90-4
  • Formula Weight
    377.14
  • Molecular Formula
    C19H18F3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCC(CC1)C(=O)c1nc(ccc1)NC(=O)c1c(cc(cc1F)F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nelson DL, et al. Cephalalgia. 2010 Oct;30(10):1159-69.
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