Lasmiditan

CAS No. 439239-90-4

Lasmiditan ( COL-144; LY573144 )

Catalog No. M18554 CAS No. 439239-90-4

Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 92 In Stock
5MG 138 In Stock
10MG 239 In Stock
25MG 525 In Stock
50MG 957 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Lasmiditan
  • Note
    Research use only, not for human use.
  • Brief Description
    Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study.
  • Description
    Lasmiditan, also known as COL-144 and LY573144, is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (K1=2.21 μM) without vasoconstrictor activity that seemed effective when given as an intravenous infusion in a proof-of-concept migraine study. Lasmiditan showed efficacy in its primary endpoint, with a 2-hour placebo-subtracted headache response of 28.8%, though with frequent reports of dizziness, paresthesias, and vertigo.
  • Synonyms
    COL-144; LY573144
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    5-HT1F
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    439239-90-4
  • Formula Weight
    377.14
  • Molecular Formula
    C19H18F3N3O2
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    CN1CCC(CC1)C(=O)c1nc(ccc1)NC(=O)c1c(cc(cc1F)F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nelson DL, et al. Cephalalgia. 2010 Oct;30(10):1159-69.
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