Laquinimod

CAS No. 248281-84-7

Laquinimod ( ABR-215062;ABR 215062;ABR215062 )

Catalog No. M13726 CAS No. 248281-84-7

Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 39 In Stock
10MG 55 In Stock
25MG 68 In Stock
50MG 88 In Stock
100MG 135 In Stock
500MG 332 In Stock
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Biological Information

  • Product Name
    Laquinimod
  • Note
    Research use only, not for human use.
  • Brief Description
    Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE).
  • Description
    Laquinimod (ABR-215062) is an immunoregulator derived from Linomide, has been shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis (EAE); dose-dependently reduces the incidence of EAN, ameliorated clinical signs and inhibited P0 peptide 180-199-specific T cell responses as well as also the decreased inflammation and demyelination in the peripheral nerves; shows improved potency and superior toxicological profile compared to the lead compound Roquinimex (Linomide).Multiple Sclerosis Approved
  • Synonyms
    ABR-215062;ABR 215062;ABR215062
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Inflammation/Immunology
  • Indication
    Multiple Sclerosis

Chemical Information

  • CAS Number
    248281-84-7
  • Formula Weight
    356.80
  • Molecular Formula
    C19H17ClN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2Cl)N(CC)C3=CC=CC=C3
  • Chemical Name
    3-Quinolinecarboxamide, 5-chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zou LP, et al. Neuropharmacology. 2002 Apr;42(5):731-9.
2. Brunmark C, et al. J Neuroimmunol. 2002 Sep;130(1-2):163-72.
3. Jnsson S, et al. J Med Chem. 2004 Apr 8;47(8):2075-88.
4. Polman C, et al. Neurology. 2005 Mar 22;64(6):987-91.
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