Cart
sales@molnova.com
Home - Products - Others - Other Targets - Lapaquistat

Lapaquistat

CAS No. 189060-13-7

Lapaquistat( TAK475 | TAK 475 | Lapaquistat acetate )

Catalog No. M12962 CAS No. 189060-13-7

A novel potent, competitive, orally active squalene synthase inhibitor with IC50 of 78 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 299 Get Quote
50MG 1143 Get Quote
100MG 1737 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    Lapaquistat
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent, competitive, orally active squalene synthase inhibitor with IC50 of 78 nM.
  • Description
    A novel potent, competitive, orally active squalene synthase inhibitor with IC50 of 78 nM; displays no effect on plasma aspartate aminotransferase and alanine aminotransferase activities; effectively inhibits cholesterol synthesis in rat liver with ED50 of 2.9 mg/kg (p.o.), lowers plasma total cholesterol, triglyceride and phospholipid levels in rabbits, also inhibits the secretion of cholesterol, triglyceride and phospholipid components of very-low-density lipoprotein (VLDL) from liver.Dyslipidemia Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male WHHLMI rabbits, aged 2 months Dosage:100 or 200?mg/kg Administration:Diet supplemented; 100 or 200?mg/kg; 32 weeks Result:Increased collagen concentration and transformed coronary plaques into fibromuscular plaques.Suppressed the expression of MMP-1 and PAI-1 in the plaque and increased peripheral coenzyme Q10 levels.
  • Synonyms
    TAK475 | TAK 475 | Lapaquistat acetate
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Other Targets
  • Research Area
    Cardiovascular Disease
  • Indication
    Dyslipidemia

Chemical Information

  • CAS Number
    189060-13-7
  • Formula Weight
    645.146
  • Molecular Formula
    C33H41ClN2O9
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(O)CC1CCN(C(C[C@H]2O[C@H](C3=CC=CC(OC)=C3OC)C4=CC(Cl)=CC=C4N(CC(C)(C)COC(C)=O)C2=O)=O)CC1
  • Chemical Name
    1-{2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-1,2,3,5-tetrahydro-2-oxo-5-(2,3-dimethoxyphenyl)-4,1-benzoxazepine-3-yl] acetyl} piperidin-4-acetic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Miki T, et al. J Med Chem. 2002 Sep 26;45(20):4571-80. 2. Amano Y, et al. Eur J Pharmacol. 2003 Apr 11;466(1-2):155-61. 3. Nishimoto T, et al. Br J Pharmacol. 2003 Jul;139(5):911-8. 4. Burnett JR. Curr Opin Investig Drugs. 2006 Sep;7(9):850-6.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Fmoc-N-PEG7-acid

    Fmoc-N-amido-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

  • Quercetin 3-O-sophor...

    Quercetin 3-O-sophoroside-7-O-rhamnoside is a natural product of Viola, Violaceae. Quercetin 3-O-sophoroside-7-O-rhamnoside can be used as a reference standard.

  • JC-1

    JC-1 is a fluorescent lipophilic carbocyanine dye. It has been used to measure mitochondrial membrane potential.?JC 1 can be used in a probe for measuring mitochondrial membrane potential by flow cytometry. JC-1 fluorescence is usually excited by the 488?nm laser wavelength common in flow cytometers. JC-1 (2.5?μM) exposed to murine L1210 lymphoblasts, can be detected the presence of both cytoplasmic JC-1 monomer and mitochondrial J-aggregates in these cells.

Sign In Join Free