Lactisole

CAS No. 150436-68-3

Lactisole ( 2-(4-Methoxyphenoxy)propanoic acid )

Catalog No. M28055 CAS No. 150436-68-3

Lactisole is an inhibitor of the glucose-sensing receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lactisole
  • Note
    Research use only, not for human use.
  • Brief Description
    Lactisole is an inhibitor of the glucose-sensing receptor.
  • Description
    Lactisole is an inhibitor of the glucose-sensing receptor.(In Vitro):In MIN6 cells, in a dose-dependent manner, lactisole inhibited insulin secretion induced by sweeteners, acesulfame-K, sucralose and glycyrrhizin. The IC50 was ~4 mmol/l. Lactisole attenuated the elevation of cytoplasmic Ca2+ concentration ([Ca2+]c) evoked by sucralose and acesulfame-K but did not affect the elevation of intracellular cAMP concentration ([cAMP]c) induced by these sweeteners. Lactisole also inhibited the action of glucose in MIN6 cells. Thus, lactisole significantly reduced elevations of intracellular [NADH] and intracellular [ATP] induced by glucose, and also inhibited glucose-induced insulin secretion.
  • Synonyms
    2-(4-Methoxyphenoxy)propanoic acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Apoptosis;PKG
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    150436-68-3
  • Formula Weight
    218.2
  • Molecular Formula
    C10H11NaO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [Na+].COc1ccc(OC(C)C([O-])=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Singh T, et al. Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis. Photochem Photobiol. 2012 Sep-Oct;88(5):1141-8.
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