LY88074

CAS No. 177744-96-6

LY88074( —— )

Catalog No. M33002 CAS No. 177744-96-6

LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 299 Get Quote
5MG 454 Get Quote
10MG 621 Get Quote
25MG 911 Get Quote
50MG 1224 Get Quote
100MG 1575 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    LY88074
  • Note
    Research use only, not for human use.
  • Brief Description
    LY88074 is a raloxifene analog in which the basic side chain has been removed. LY88074 is an agonist of ERβ (EC50 = 232 nM).This compound stimulates uterine cell proliferation.
  • Description
    LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner.
  • In Vitro
    Removal of the aminoethylpiperdine moiety, as in LY88074 (Compound 88074), reduces bone binding, compared to Raloxifene. The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    Estrogen/progestogen Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    177744-96-6
  • Formula Weight
    362.4
  • Molecular Formula
    C21H14O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(O)C=C4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bivi N, et al. Structural features underlying raloxifene's biophysical interaction with bone matrix. Bioorg Med Chem. 2016 Feb 15;24(4):759-67.?
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