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Home - Products - Metabolic Enzyme/Protease - PPAR - LY518674

LY518674

CAS No. 425671-29-0

LY518674( LY-674 )

Catalog No. M24391 CAS No. 425671-29-0

LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 357 In Stock
10MG 530 In Stock
25MG 851 In Stock
50MG 1152 In Stock
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Biological Information

  • Product Name
    LY518674
  • Note
    Research use only, not for human use.
  • Brief Description
    LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis.
  • Description
    LY518674 decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα antagonist (EC50: 42 nM for human PPARα).
  • In Vitro
    ——
  • In Vivo
    LY518674 reduces triglycerides and increased HDL-C in vivo.LY518674 substantially increases apolipoprotein A-I (apoA-I) turnover without major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) .
  • Synonyms
    LY-674
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PPAR
  • Recptor
    PPARα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    425671-29-0
  • Formula Weight
    409.48
  • Molecular Formula
    C23H27N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (610.53 mM; Need ultrasonic)
  • SMILES
    CC(C)(C(O)=O)Oc1ccc(CCCC(N2)=NN(Cc3ccc(C)cc3)C2=O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bravo Y, et al. Identification of the first potent, selective and bioavailable PPARα antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72.
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