
LY310762
CAS No. 192927-92-7
LY310762( LY310762 | LY 310762 | LY-310762 )
Catalog No. M18182 CAS No. 192927-92-7
LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 41 | In Stock |
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10MG | 65 | In Stock |
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25MG | 132 | In Stock |
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100MG | 344 | In Stock |
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200MG | 521 | In Stock |
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500MG | Get Quote | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameLY310762
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NoteResearch use only, not for human use.
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Brief DescriptionLY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
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DescriptionLY310762 is a 5-HT1D antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
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In VitroLY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM.LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).
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In VivoLY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo.LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model. Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan).Dosage:10 mg/kg Administration:Intraperitoneal injection; single Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model).Dosage:1 mg/kg Administration:Intravenous injection; single Result:Completely abolished 5-HT vasodilator effects.
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SynonymsLY310762 | LY 310762 | LY-310762
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PathwayOthers
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TargetAntioxidant
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Recptor5-HT1D
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number192927-92-7
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Formula Weight430.94
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Molecular FormulaC24H27FN2O2·HCl
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 44 mg/mL; 102.10 mM
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SMILESCl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
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Chemical Name1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-dimethylindolin-2-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pullar IA, et al. Eur J Pharmacol, 2004, 493(1-3), 85-93.
molnova catalog



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