LY310762

CAS No. 192927-92-7

LY310762( LY310762 | LY 310762 | LY-310762 )

Catalog No. M18182 CAS No. 192927-92-7

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 65 In Stock
25MG 132 In Stock
100MG 344 In Stock
200MG 521 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    LY310762
  • Note
    Research use only, not for human use.
  • Brief Description
    LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
  • Description
    LY310762 is a 5-HT1D antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
  • In Vitro
    LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM.LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).
  • In Vivo
    LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo.LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model. Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan).Dosage:10 mg/kg Administration:Intraperitoneal injection; single Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model).Dosage:1 mg/kg Administration:Intravenous injection; single Result:Completely abolished 5-HT vasodilator effects.
  • Synonyms
    LY310762 | LY 310762 | LY-310762
  • Pathway
    Others
  • Target
    Antioxidant
  • Recptor
    5-HT1D
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    192927-92-7
  • Formula Weight
    430.94
  • Molecular Formula
    C24H27FN2O2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 44 mg/mL; 102.10 mM
  • SMILES
    Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
  • Chemical Name
    1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-dimethylindolin-2-one hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pullar IA, et al. Eur J Pharmacol, 2004, 493(1-3), 85-93.
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