LY310762

CAS No. 192927-92-7

LY310762( LY310762 | LY 310762 | LY-310762 )

Catalog No. M18182 CAS No. 192927-92-7

LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 65 In Stock
25MG 132 In Stock
100MG 344 In Stock
200MG 521 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    LY310762
  • Note
    Research use only, not for human use.
  • Brief Description
    LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.
  • Description
    LY310762 is a 5-HT1D antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.
  • In Vitro
    LY310762 (0.01-1 μM) shows potentiation of potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 value of 31 nM.LY310762 (10 μM) significantly but not completely blocks the extent of sumatriptan-induced decrease in EPSCs (excitatory postsynaptic potential).
  • In Vivo
    LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo.LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model. Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan).Dosage:10 mg/kg Administration:Intraperitoneal injection; single Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model).Dosage:1 mg/kg Administration:Intravenous injection; single Result:Completely abolished 5-HT vasodilator effects.
  • Synonyms
    LY310762 | LY 310762 | LY-310762
  • Pathway
    Others
  • Target
    Antioxidant
  • Recptor
    5-HT1D
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    192927-92-7
  • Formula Weight
    430.94
  • Molecular Formula
    C24H27FN2O2·HCl
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 44 mg/mL; 102.10 mM
  • SMILES
    Cl.CC1(C)C(=O)N(CCN2CCC(CC2)C(=O)c2ccc(F)cc2)c2ccccc12
  • Chemical Name
    1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-dimethylindolin-2-one hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pullar IA, et al. Eur J Pharmacol, 2004, 493(1-3), 85-93.
molnova catalog
related products
  • LY310762

    LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM.

  • Neochlorogenic acid ...

    Neochlorogenic acid methyl ester is derived from Artemisia capillaris and black chokeberry (Aronia melanocarpa) fruits. Neochlorogenic acid methyl ester shows weak anti-HBV activity, antioxidant and quinone reductase activity with CD of 6.7 μM.

  • 4-Decanol

    4-Decanol, a compound isolated from the roots of Valeriana jatamansi Jones and Epilobium angustifolium L., may have anti-inflammatory and antioxidant activities.