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LY2955303

CAS No. 1433497-19-8

LY2955303( —— )

Catalog No. M26746 CAS No. 1433497-19-8

LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LY2955303
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
  • Description
    LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).(In Vitro):The functional Ki for RARγ is 7.1±4.9 nM. The binding Kis of LY2955303 for RARα, RARβ, and RARγ are >1700, >2980, and 1.09 nM, respectively.(In Vivo):A single dose of LY2955303(oral) showed a dose-response effect in rats with different weight-bearing reductions with an ED50 of 0.72 mg/kg.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1433497-19-8
  • Formula Weight
    578.757
  • Molecular Formula
    C36H42N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 30 mg/mL (51.84 mM)
  • SMILES
    CN1CCN(CC1)C(=O)c1ccc(cc1)-n1nc(cc1-c1cc(cc(c1)C(C)(C)C)C(C)(C)C)-c1ccc(cc1)C(O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hatayama M, et al. Acute Effects of Oral Tofisopam on Plasma Concentration and Urinary Excretion of Uric Acid and Oxypurinol. Curr Clin Pharmacol. 2015 Jan 26.
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