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LY2922470

CAS No. 1423018-12-5

LY2922470( LY-2922470 | LY 2922470 )

Catalog No. M11781 CAS No. 1423018-12-5

LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM; displays no activity against PPARα/β/γ (>10 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 224 Get Quote
10MG 337 Get Quote
25MG 584 Get Quote
50MG 833 Get Quote
100MG 1134 Get Quote
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Biological Information

  • Product Name
    LY2922470
  • Note
    Research use only, not for human use.
  • Brief Description
    LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM; displays no activity against PPARα/β/γ (>10 uM).
  • Description
    LY2922470 (LY-2922470) is a potent, selective, orally available GPR40 agonist with EC50 of 7 nM; displays no activity against PPARα/β/γ (>10 uM); demonstrates potent, efficacious, and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion in vivo.Diabetes Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LY-2922470 | LY 2922470
  • Pathway
    GPCR/G Protein
  • Target
    FFAR
  • Recptor
    FFAR
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1423018-12-5
  • Formula Weight
    475.603
  • Molecular Formula
    C28H29NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 125 mg/mL 262.83 mM
  • SMILES
    O=C(C[C@@H](C1=CC=C(OCC2=CC=C(CN3CCCC4=C3C(OC)=CC=C4)S2)C=C1)C#CC)O
  • Chemical Name
    (S)-3-(4-((5-((8-methoxy-3,4-dihydroquinolin-1(2H)-yl)methyl)thiophen-2-yl)methoxy)phenyl)hex-4-ynoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hamdouchi C, et al. J Med Chem. 2016 Dec 22;59(24):10891-10916.
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