LY2452473( TT 701 | OPK 88004 )

Catalog No. M10141 CAS No. 1029692-15-6

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Product Name

LY2452473
Note

Research use only, not for human use.
Brief Description

LY2452473 (TT 701;OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism.
Description

LY2452473 (TT 701;OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism; has the potential advantage of eliciting androgen receptor specificity and tissue selectivity to produce the beneficial effects of testosterone on bone, muscle, and improvements in erectile function over a PDE5i alone, with minimal steroid-related adverse effects.Prostate Cancer Phase 2 Clinical.
In Vitro

——
In Vivo

LY2452473 is a selective androgen receptor modulator being developed for the treatment of disorders related to hypogonadism. LY2452473 is absorbed rapidly (time to reach maximum plasma concentration for both LY2452473 and total radioactivity is 2-3 h) and cleared slowly (plasma terminal t1/2 of 27 h for LY2452473 and 51 h for the total radioactivity).
Synonyms

TT 701 | OPK 88004
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

Cancer
Indication

Prostate Cancer

CAS Number

1029692-15-6
Formula Weight

374.444
Molecular Formula

C22H22N4O2
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 166.92 mM
SMILES

O=C(OC(C)C)N[C@H](C1)CC2=C1N(CC3=NC=CC=C3)C4=C2C=C(C#N)C=C4
Chemical Name

Isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

1. Yi P, et al. Drug Metab Dispos. 2012 Dec;40(12):2354-64. 2. Noey EL, et al. J Org Chem. 2017 Jun 2;82(11):5904-5909.

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