LY2452473 ( TT 701;OPK 88004 )

Catalog No. M10141 CAS No. 1029692-15-6

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Product Name

LY2452473
Note

Research use only, not for human use.
Brief Description

LY2452473 (TT 701;OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism.
Description

LY2452473 (TT 701;OPK 88004) is an orally bioavailable selective androgen receptor modulator (SARM) being developed for the treatment of disorders related to hypogonadism; has the potential advantage of eliciting androgen receptor specificity and tissue selectivity to produce the beneficial effects of testosterone on bone, muscle, and improvements in erectile function over a PDE5i alone, with minimal steroid-related adverse effects.Prostate Cancer Phase 2 Clinical
Synonyms

TT 701;OPK 88004
Pathway

Endocrinology/Hormones
Target

Androgen Receptor (AR)
Recptor

Androgen Receptor (AR)
Research Area

Cancer
Indication

Prostate Cancer

CAS Number

1029692-15-6
Formula Weight

374.44
Molecular Formula

C22H22N4O2
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 166.92 mM
SMILES

O=C(OC(C)C)N[C@H](C1)CC2=C1N(CC3=NC=CC=C3)C4=C2C=C(C#N)C=C4
Chemical Name

Isopropyl N-[(2S)-7-cyano-4-(2-pyridylmethyl)-2,3-dihydro-1H-cyclopenta[b]indol-2-yl]carbamate

1. Yi P, et al. Drug Metab Dispos. 2012 Dec;40(12):2354-64.
2. Noey EL, et al. J Org Chem. 2017 Jun 2;82(11):5904-5909.

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