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LY2109761
CAS No. 700874-71-1
LY2109761( LY 2109761 | LY-2109761 )
Catalog No. M15688 CAS No. 700874-71-1
A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 35 | In Stock |
|
| 5MG | 58 | In Stock |
|
| 10MG | 102 | In Stock |
|
| 25MG | 178 | In Stock |
|
| 50MG | 318 | In Stock |
|
| 100MG | 480 | In Stock |
|
| 200MG | 692 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY2109761
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively.
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DescriptionA potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively; completely inhibits TGF-β-induced Sma2 phosphorylation on tumor cells or the liver microenviroment, inhibits the L3.6pl/GLT soft agar growth, suppresses both basal and TGF-β1-induced cell migration and invasion, and stimulates anoikis in vitro; significantly reduces the tumor burden as well as spontaneous abdominal metastases, and prolongs survival combined with gemicitabine in vivo model of pancreatic cancer.
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In Vitro——
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In Vivo——
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SynonymsLY 2109761 | LY-2109761
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTβRI|TβRII
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number700874-71-1
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Formula Weight441.5249
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Molecular FormulaC26H27N5O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESN1(CCOC2=CC=C3C(C4=C(CCC5)N5N=C4C6=NC=CC=C6)=CC=NC3=C2)CCOCC1
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Chemical NameQuinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mazzocca A, et al. Hepatology. 2009 Oct;50(4):1140-51.
2. Zhang M, et al. Cancer Res, 2011, 71(23), 7155-7167.
3. Melisi D, et al. Mol Cancer Ther, 2008, 7(4), 829-840.
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