LY2109761

CAS No. 700874-71-1

LY2109761( LY 2109761 | LY-2109761 )

Catalog No. M15688 CAS No. 700874-71-1

A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 35 In Stock
5MG 58 In Stock
10MG 102 In Stock
25MG 178 In Stock
50MG 318 In Stock
100MG 480 In Stock
200MG 692 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    LY2109761
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively.
  • Description
    A potent, selective and orally active TGF-β RI/II dual inhibitor with Ki of 38/300 nM, respectively; completely inhibits TGF-β-induced Sma2 phosphorylation on tumor cells or the liver microenviroment, inhibits the L3.6pl/GLT soft agar growth, suppresses both basal and TGF-β1-induced cell migration and invasion, and stimulates anoikis in vitro; significantly reduces the tumor burden as well as spontaneous abdominal metastases, and prolongs survival combined with gemicitabine in vivo model of pancreatic cancer.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    LY 2109761 | LY-2109761
  • Pathway
    TGF-beta/Smad
  • Target
    TGFBR
  • Recptor
    TβRI|TβRII
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    700874-71-1
  • Formula Weight
    441.5249
  • Molecular Formula
    C26H27N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    N1(CCOC2=CC=C3C(C4=C(CCC5)N5N=C4C6=NC=CC=C6)=CC=NC3=C2)CCOCC1
  • Chemical Name
    Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mazzocca A, et al. Hepatology. 2009 Oct;50(4):1140-51. 2. Zhang M, et al. Cancer Res, 2011, 71(23), 7155-7167. 3. Melisi D, et al. Mol Cancer Ther, 2008, 7(4), 829-840.
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