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LY-354740
CAS No. 176199-48-7
LY-354740( Eglumegad | Eglumetad )
Catalog No. M12658 CAS No. 176199-48-7
A potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM; possesses no activity at iGluR or group 1 mGluR (>100 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 200MG | 1125 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLY-354740
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM; possesses no activity at iGluR or group 1 mGluR (>100 uM).
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DescriptionA potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM; possesses no activity at iGluR or group 1 mGluR (>100 uM); shows anticonvulsant and anxiolytic properties in vivo; orally active.Schizophrenia Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsEglumegad | Eglumetad
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PathwayGPCR/G Protein
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TargetmGluR
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RecptormGluR
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Research AreaNeurological Disease
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IndicationSchizophrenia
Chemical Information
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CAS Number176199-48-7
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Formula Weight185.1772
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Molecular FormulaC8H11NO4
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Purity>98% (HPLC)
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SolubilityDMSO: < 1.9 mg/mL
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SMILESO=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])CC1)O
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Chemical NameBicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Monn JA, et al. J Med Chem. 1997 Feb 14;40(4):528-37.
2. Menezes MM, et al. Neurosci J. 2013;2013:736439.
3. Profaci CP, et al. Psychopharmacology (Berl). 2011 Jul;216(2):235-43.
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