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LUT014

CAS No. 2274819-46-2

LUT014( —— )

Catalog No. M24036 CAS No. 2274819-46-2

LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LUT014
  • Note
    Research use only, not for human use.
  • Brief Description
    LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
  • Description
    LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    Raf
  • Recptor
    B-Raf
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2274819-46-2
  • Formula Weight
    528.49
  • Molecular Formula
    C27H19F3N8O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:50 mg/mL (94.61 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
  • SMILES
    Cc1ccc2c(Nc3cccc(OC(F)(F)F)c3)nccc2c1Nc1ncccc1-c1ncnc2c1[nH]cn2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Noa Shelach. Novel braf inhibitors and use there of for treatment of cutaneous reactions. WO2019026065A2.
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