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LUF6000
CAS No. 890087-21-5
LUF6000( LUF-6000 | LUF 6000 )
Catalog No. M16423 CAS No. 890087-21-5
LUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 294 | Get Quote |
|
| 50MG | 897 | Get Quote |
|
| 100MG | 1575 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLUF6000
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NoteResearch use only, not for human use.
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Brief DescriptionLUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor.
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DescriptionLUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor, enhance Emax but without affecting agonist potency; enhance sagonist efficacy in a functional assay by 45% and decreases dissociation rate similarly without influencing agonist potency, LUF6000 is superior to that of DU124183.
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In VitroModulatory effect of 10 μM LUF6000 on Cl-IB-MECA-induced [35S]GTPγS binding in assays with HEK 293 cell membranes expressing human, dog, rabbit, or mouse A3 adenosine receptors with EC50 ranging from 39 to 172 nM.
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In VivoLUF6000 induces anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice.
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SynonymsLUF-6000 | LUF 6000
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PathwayApoptosis
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TargetAdenosine Receptor
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RecptorAdenosine Receptor
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number890087-21-5
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Formula Weight411.327
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Molecular FormulaC22H20Cl2N4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESClC1=CC=C(NC2=NC3=CC=CC=C3C4=C2NC(C5CCCCC5)=N4)C=C1Cl
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Chemical Name3H-Imidazo[4,5-c]quinolin-4-amine, 2-cyclohexyl-N-(3,4-dichlorophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. G?bly?s A, et al. J Med Chem. 2006 Jun 1;49(11):3354-61.
2. Gao ZG, et al. BMC Pharmacol. 2008 Dec 12;8:20.
3. Gao ZG, et al. Biochem Pharmacol. 2011 Sep 15;82(6):658-68.
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