Cart
sales@molnova.com
LUF6000
CAS No. 890087-21-5
LUF6000( LUF-6000 | LUF 6000 )
Catalog No. M16423 CAS No. 890087-21-5
LUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 294 | Get Quote |
|
| 50MG | 897 | Get Quote |
|
| 100MG | 1575 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLUF6000
-
NoteResearch use only, not for human use.
-
Brief DescriptionLUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor.
-
DescriptionLUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor, enhance Emax but without affecting agonist potency; enhance sagonist efficacy in a functional assay by 45% and decreases dissociation rate similarly without influencing agonist potency, LUF6000 is superior to that of DU124183.
-
In VitroModulatory effect of 10 μM LUF6000 on Cl-IB-MECA-induced [35S]GTPγS binding in assays with HEK 293 cell membranes expressing human, dog, rabbit, or mouse A3 adenosine receptors with EC50 ranging from 39 to 172 nM.
-
In VivoLUF6000 induces anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice.
-
SynonymsLUF-6000 | LUF 6000
-
PathwayApoptosis
-
TargetAdenosine Receptor
-
RecptorAdenosine Receptor
-
Research AreaCardiovascular Disease
-
Indication——
Chemical Information
-
CAS Number890087-21-5
-
Formula Weight411.327
-
Molecular FormulaC22H20Cl2N4
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESClC1=CC=C(NC2=NC3=CC=CC=C3C4=C2NC(C5CCCCC5)=N4)C=C1Cl
-
Chemical Name3H-Imidazo[4,5-c]quinolin-4-amine, 2-cyclohexyl-N-(3,4-dichlorophenyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. G?bly?s A, et al. J Med Chem. 2006 Jun 1;49(11):3354-61.
2. Gao ZG, et al. BMC Pharmacol. 2008 Dec 12;8:20.
3. Gao ZG, et al. Biochem Pharmacol. 2011 Sep 15;82(6):658-68.
molnova catalog
related products
-
8-Azaadenosine
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor.
-
Pentoxifylline
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology.
-
DL-Norepinephrine hy...
DL-Norepinephrine hydrochloride is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM.
