Cart
sales@molnova.com
Home - Products - Apoptosis - Adenosine Receptor - LUF6000

LUF6000

CAS No. 890087-21-5

LUF6000( LUF-6000 | LUF 6000 )

Catalog No. M16423 CAS No. 890087-21-5

LUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 294 Get Quote
50MG 897 Get Quote
100MG 1575 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    LUF6000
  • Note
    Research use only, not for human use.
  • Brief Description
    LUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor.
  • Description
    LUF6000 is a potent, selective, positive allosteric modulator (enhancer) of human A3 adenosine receptor, enhance Emax but without affecting agonist potency; enhance sagonist efficacy in a functional assay by 45% and decreases dissociation rate similarly without influencing agonist potency, LUF6000 is superior to that of DU124183.
  • In Vitro
    Modulatory effect of 10 μM LUF6000 on Cl-IB-MECA-induced [35S]GTPγS binding in assays with HEK 293 cell membranes expressing human, dog, rabbit, or mouse A3 adenosine receptors with EC50 ranging from 39 to 172 nM.
  • In Vivo
    LUF6000 induces anti-inflammatory effect in 3 experimental animal models of rat adjuvant induced arthritis, monoiodoacetate induced osteoarthritis, and concanavalin A induced liver inflammation in mice.
  • Synonyms
    LUF-6000 | LUF 6000
  • Pathway
    Apoptosis
  • Target
    Adenosine Receptor
  • Recptor
    Adenosine Receptor
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    890087-21-5
  • Formula Weight
    411.327
  • Molecular Formula
    C22H20Cl2N4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    ClC1=CC=C(NC2=NC3=CC=CC=C3C4=C2NC(C5CCCCC5)=N4)C=C1Cl
  • Chemical Name
    3H-Imidazo[4,5-c]quinolin-4-amine, 2-cyclohexyl-N-(3,4-dichlorophenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. G?bly?s A, et al. J Med Chem. 2006 Jun 1;49(11):3354-61. 2. Gao ZG, et al. BMC Pharmacol. 2008 Dec 12;8:20. 3. Gao ZG, et al. Biochem Pharmacol. 2011 Sep 15;82(6):658-68.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • KI-7

    KI-7 is an adenosine A2B receptor positive allosteric modulator.

  • MSX-3 hydrate

    MSX-3 hydrate is a potent, specific adenosine A2A receptor (A2AR) antagonist.

  • Labetalol

    Labetalol is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situations. The pharmacokinetics of labetalol is affected by the common CYP2C19 polymorphisms.

Sign In Join Free