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LTX-315

CAS No. 1345407-05-7

LTX-315 ( Oncopore )

Catalog No. M11383 CAS No. 1345407-05-7

LTX-315 (Oncopore) is a synthetic 9-mer anticancer peptide that preferentially permeabilizes mitochondrial membranes.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 194 In Stock
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Biological Information

  • Product Name
    LTX-315
  • Note
    Research use only, not for human use.
  • Brief Description
    LTX-315 (Oncopore) is a synthetic 9-mer anticancer peptide that preferentially permeabilizes mitochondrial membranes.
  • Description
    LTX-315 (Oncopore) is a synthetic 9-mer anticancer peptide that preferentially permeabilizes mitochondrial membranes, thereby causing partially BAX/BAK1-regulated, caspase-independent necrosis; triggers immunogenic cell death, induces cell death and DAMP release by mitochondria distortion in human melanoma cells.Breast Cancer Phase 2 Clinical
  • Synonyms
    Oncopore
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1345407-05-7
  • Formula Weight
    1439.82
  • Molecular Formula
    C78H106N18O9
  • Purity
    >98% (HPLC)
  • Solubility
    Ethanol: 100 mg/mL (69.45 mM); DMSO: <1 mg/mL; Water: 100 mg/mL (69.45 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    NCCCC[C@@H](C(N)=O)NC([C@H](C(C1=CC=CC=C1)C2=CC=CC=C2)NC([C@H](CC3=CNC4=C3C=CC=C4)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC5=CNC6=C5C=CC=C6)NC([C@H](CC7=CNC8=C7C=CC=C8)NC([C@H](CCCCN)NC([C@H](CCCCN)N)=O)=O)=O)=O)=O)=O)=O)=O
  • Chemical Name
    L-Lysyl-L-lysyl-L-tryptophyl-L-tryptophyl-L-lysyl-L-lysyl-L-tryptophyl-β-phenyl-L-phenylalanyl-L-lysinamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Haug BE, et al. J Med Chem. 2016 Apr 14;59(7):2918-27.
2. Forveille S, et al. Cell Cycle. 2015;14(21):3506-12.
3. Zhou H, et al. Oncotarget. 2015 Sep 29;6(29):26599-614.
4. Eike LM, et al. Oncotarget. 2015 Oct 27;6(33):34910-23.
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