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LS-102

CAS No. 1456891-34-1

LS-102( ——— )

Catalog No. M38018 CAS No. 1456891-34-1

LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LS-102
  • Note
    Research use only, not for human use.
  • Brief Description
    LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor. LS-102 inhibits the autoubiquitination of synoviolin with an IC50 of 35 μM. LS-102 has the potential for rheumatoid arthritis treatment.
  • Description
    LS-102 is a selective E3 ubiquitin ligase synoviolin (Syvn1) inhibitor.
  • In Vitro
    Cell Viability Assay Cell Line:Rheumatoid synovial cells (RSCs) m Concentration:20, 40, 60 μM Incubation Time:12 hours Result:Inhibited proliferation of RSCs with an IC50 of 5.4 μM.
  • In Vivo
    Animal Model:7-week-old DBA/1 male mice (CIA model) Dosage:1.3, 4.0 mg/kg Administration:I.p.; daily for 4 weeks Result:Reduced the clinical severity scores.
  • Synonyms
    ———
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ———
  • Research Area
    ———
  • Indication
    ———

Chemical Information

  • CAS Number
    1456891-34-1
  • Formula Weight
    452.6
  • Molecular Formula
    C24H36N8O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL (220.95 mM )
  • SMILES
    ———
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yagishita N, et al. RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoidarthritis. Int J Mol Med. 2012 Dec;30(6):1281-6.?
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