Cart
sales@molnova.com
LR-90
CAS No. 245075-84-7
LR-90 ( —— )
Catalog No. M26283 CAS No. 245075-84-7
LR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 87 | Get Quote |
|
| 5MG | 147 | Get Quote |
|
| 10MG | 258 | Get Quote |
|
| 25MG | 484 | Get Quote |
|
| 50MG | 700 | Get Quote |
|
| 100MG | 981 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameLR-90
-
NoteResearch use only, not for human use.
-
Brief DescriptionLR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.?
-
DescriptionLR-90 is also used in the research of diabetic animal model.LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes.?(In Vitro):LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours.?LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells.LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours.(In Vivo):LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorBRD4
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number245075-84-7
-
Formula Weight709.6
-
Molecular FormulaC35H34Cl2N4O8
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCC(C)(Oc1ccc(NC(=O)Nc2ccc(Cc3ccc(NC(=O)Nc4ccc(OC(C)(C)C(O)=O)cc4)c(Cl)c3)cc2Cl)cc1)C(O)=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Neuromedin U, rat
Neuromedin U,a 23-amino acid brain-gut peptide, regulates several important physiological functions through its cognate receptor NMUR2 in the central nervous system, including energy balance, stress response, and nociception.
-
L-allo-Isoleucine
L-alloisoleucine is a branched chain amino acid and is a stereoisomer of L-isoleucine. It is a common constituent of human plasma (albeit at low levels). L-alloisoleucine is produced as a byproduct of isoleucine transamination. Plasma L-alloisoleucine which is derived from L-isoleucine in vivo can be used for the diagnosis of maple syrup urine disease (MSUD) a genetic disorder.
-
Zanthobungeanine
Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.It shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). Zanthobungeanine shows the inhibitory action on the development of A549 cell only in high concentration and has no antipersonnel effect on A549 cell.
