LN-1-255

Research use only, not for human use.

LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor.

LN-1-255 is a 6-alkylidene-2'-substituted penicillin sulfone that acts as an effective beta-lactamase inhibitor; inhibits SHV-1 and SHV-2 beta-lactamases with Ki of 110 nM and 100 nM, significantly enhances the activity of ceftazidime and cefpirome against extended-spectrum cephalosporin and Sme-1 containing carbapenem-resistant clinical strains; also inhibits the class D carbapenemase OXA-48 with IC50 of 3 nM, an important emerging mechanism of antibiotic resistance.

LN 1-255;LN1255

GPCR/G Protein

Antibacterial

Antibacterial

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247115-03-3

510.45

C22H19N2NaO9S

>98% (HPLC)

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4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-[[[(3,4-dihydroxyphenyl)acetyl]oxy]methyl]-3-methyl-7-oxo-6-(2-pyridinylmethylene)-, 4,4-dioxide, monosodium salt, (2S,3R,5R,6Z)- (9CI)

(-20℃)

With Ice Pack

≥ 2 years