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LMTK3-IN-1

CAS No. 2764850-23-7

LMTK3-IN-1( —— )

Catalog No. M36996 CAS No. 2764850-23-7

Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	73	Get Quote
5MG	107	Get Quote
10MG	169	Get Quote
25MG	273	Get Quote
50MG	417	Get Quote
100MG	590	Get Quote
500MG	1224	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

LMTK3-IN-1
Note

Research use only, not for human use.
Brief Description

Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.
Description

LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Angiogenesis
Target

c-Met/HGFR
Recptor

c-Met/HGFR
Research Area

——
Indication

——

Chemical Information

CAS Number

2764850-23-7
Formula Weight

356.3
Molecular Formula

C18H11F3N4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 5 mg/mL (14.03 mM; Ultrasonic (<60°C)
SMILES

FC(F)(F)OC1=CC=CC(=C1)C2=CN=C3C=CC(=NN32)C=4C=CN=CC4
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865.?

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