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LM22A-4
CAS No. 37988-18-4
LM22A-4( —— )
Catalog No. M20852 CAS No. 37988-18-4
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB;?IC50 : 47 nM in a fluorescence anisotropy assay).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | Get Quote |
|
| 10MG | 65 | Get Quote |
|
| 25MG | 140 | Get Quote |
|
| 50MG | 245 | Get Quote |
|
| 100MG | 430 | Get Quote |
|
| 500MG | 945 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLM22A-4
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NoteResearch use only, not for human use.
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Brief DescriptionLM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB;?IC50 : 47 nM in a fluorescence anisotropy assay).
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DescriptionLM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB;?IC50 : 47 nM in a fluorescence anisotropy assay).
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In VitroLM22A-4 significantly up-regulates OPN and ALPase mRNA expression in a dose-dependent manner and OC mRNA level is significantly increased by 5 μM of LM22A-4. LM22A-4 significantly increases OPN, ALPase and OC mRNA expression in a time-dependent manner. LM22A-4 stimulated OPN and OC mRNA expression in HCEM cells cultured with mineralizing media.
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In VivoLM22A-4 (10 mg/kg, i.p.) significantly reduces the degree of tissue injury and apoptosis (TUNEL staining and caspase-3 and Bcl-2 expression) compared with vehicle treated group. LM22A-4 also significantly ameliorates the recovery of limb function. LM22A-4 (10 mg/kg) treatment results in a significant increase in neuron number. LM22A-4 administration (10 mg/kg) significantly improves the neurological scores compared with those of the solvent-treated animals.
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Synonyms——
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PathwayTyrosine Kinase
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TargetTrk Receptor
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RecptorTrk
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Research Area——
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Indication——
Chemical Information
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CAS Number37988-18-4
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Formula Weight339.34
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Molecular FormulaC15H21N3O6
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Purity>98% (HPLC)
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SolubilityH2O:50 mg/mL (147.34 mM);DMSO:29 mg/mL (85.46 mM)
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SMILESO=C(NCCO)c1cc(C(=O)NCCO)cc(C(=O)NCCO)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Schmid D A Yang T Ogier M et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 2012 32(5):1803-1810.
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