LLY-507 ( LLY-507; LLY 507; LLY507 )

Catalog No. M12702 CAS No. 1793053-37-8

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Product Name

LLY-507
Note

Research use only, not for human use.
Brief Description

A potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM).
Description

A potent, selective and cell-active inhibitor of SMYD2 (IC50<15 nM); displays >100-fold selective over a broad range of methyltransferase and non-methyltransferase targets; inhibits SMYD2-mediated methylation of p53 Lys370 and suppresses proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner (IC50=1.5-6 uM).
Synonyms

LLY-507; LLY 507; LLY507
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

SMYD2
Research Area

Cancer
Indication

——

CAS Number

1793053-37-8
Formula Weight

574.76
Molecular Formula

C36H42N6O
Purity

>98% (HPLC)
Solubility

DMSO: 15 mg/mL
SMILES

O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6
Chemical Name

[1,1'-Biphenyl]-3-carboxamide, 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-

1. Nguyen H, et al. J Biol Chem. 2015 May 29;290(22):13641-53.
2. Olsen JB, et al. Mol Cell Proteomics. 2016 Mar;15(3):892-905.

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