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Home - Products - Chromatin/Epigenetic - HMTase - LEM-14

LEM-14

CAS No. 1814881-70-3

LEM-14 ( LEM14; LEM 14; LEM-14 )

Catalog No. M12786 CAS No. 1814881-70-3

LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LEM-14
  • Note
    Research use only, not for human use.
  • Brief Description
    LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM.
  • Description
    LEM-14 is a specific inhibitor of histone lysine methyltransferase NSD2 (MMSET/WHSC1) with in vitro IC50 of 132 uM, and that is inactive against the closely related NSD1 and NSD3.
  • Synonyms
    LEM14; LEM 14; LEM-14
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1814881-70-3
  • Formula Weight
    478.57
  • Molecular Formula
    C25H26N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C(C2=C(CCCC2)S3)=C3N=C(CN4CCN(C([C@@H](CC5=C6C=CC=C5)OC6=O)=O)CC4)N1
  • Chemical Name
    (R)-2-((4-(1-oxoisochromane-3-carbonyl)piperazin-1-yl)methyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shen Y, et al. Biochem Biophys Res Commun. 2018 Nov 21. pii: S0006-291X(18)32443-4.
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