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LEI-401
CAS No. 2393840-15-6
LEI-401( —— )
Catalog No. M34998 CAS No. 2393840-15-6
LEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLEI-401
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NoteResearch use only, not for human use.
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Brief DescriptionLEI-401 is a selective and potent NAPE-PLD inhibitor that crosses the blood-brain barrier (IC50: 27 nM).LEI-401 reduces the level of n-acylethanolamines (NAEs) in the brain of free-ranging mice and modulates their emotional behaviour.
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DescriptionLEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice.
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In Vitro——
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In VivoAnimal Model:Male 7–12-week-old C57BL/6J mice Dosage:30?mg/kg Administration:I.p.Result:Produced a significant increase in freezing as compared to vehicle.Animal Model:C57BL/6J mice Dosage:10 mg/kg Administration:P.o. (Pharmacokinetic Analysis) Result:The t1/2, Cmax, tmax, AUClast, and F values were 2.5 hours, 1370 ng/mL, 2 hours, 6760 h*ng/mL, and 25%, respectively.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhospholipase
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RecptorPhospholipase
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Research Area——
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Indication——
Chemical Information
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CAS Number2393840-15-6
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Formula Weight421.54
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Molecular FormulaC24H31N5O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (237.23 mM; Ultrasonic )
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SMILESO[C@H]1CCN(C1)c1cc(nc(n1)N1CCC[C@H](C1)c1ccccc1)C(=O)NCC1CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mock ED, et al. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nat Chem Biol. 2020;16(6):667-675.?
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