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LDC7559

CAS No. 2407782-01-6

LDC7559 ( —— )

Catalog No. M26276 CAS No. 2407782-01-6

LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

LDC7559
Note

Research use only, not for human use.
Brief Description

LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
Description

LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.(In Vitro):LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

VHL
Research Area

——
Indication

——

Chemical Information

CAS Number

2407782-01-6
Formula Weight

349.4
Molecular Formula

C20H19N3O3
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(NC1=CC=C2C(OCC3=CC(=NN3C2)C=4C=CC=CC4OC)=C1)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

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