L82

CAS No. 329227-30-7

L82( —— )

Catalog No. M35468 CAS No. 329227-30-7

L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 61 Get Quote
10MG 100 Get Quote
25MG 181 Get Quote
50MG 288 Get Quote
100MG 447 Get Quote
500MG 972 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    L82
  • Note
    Research use only, not for human use.
  • Brief Description
    L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
  • Description
    L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells.
  • In Vitro
    L82 (0-50 μM; 6 d) shows anti-proliferative activity to breast cancer cells.L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.Cell Proliferation Assay Cell Line:MCF10A, MCF7, HCT116, and HeLa cells Concentration:0-50 μM Incubation Time:6 days Result:Reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa and HCT116, in a concentration-dependent manner.Cell Cycle Analysis Cell Line:MCF7 cells Concentration:50 μM Incubation Time:0-48 hours Result:Showed a transient accumulation of cells at G2/M after 12 h, then showed an accumulation at G0/G1 that peaked after 24 h.Decreased in the S phase cell in accompany with the increase in the G0/G1 phase.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    329227-30-7
  • Formula Weight
    309.67
  • Molecular Formula
    C11H8ClN5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (107.63 mM; Ultrasonic )
  • SMILES
    Oc1ccc(\C=N\Nc2cn[nH]c(=O)c2Cl)cc1[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.?
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