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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - L82

L82

CAS No. 329227-30-7

L82( —— )

Catalog No. M35468 CAS No. 329227-30-7

L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    L82
  • Note
    Research use only, not for human use.
  • Brief Description
    L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
  • Description
    L82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells.
  • In Vitro
    L82 (0-50 μM; 6 d) shows anti-proliferative activity to breast cancer cells.L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.Cell Proliferation Assay Cell Line:MCF10A, MCF7, HCT116, and HeLa cells Concentration:0-50 μM Incubation Time:6 days Result:Reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa and HCT116, in a concentration-dependent manner.Cell Cycle Analysis Cell Line:MCF7 cells Concentration:50 μM Incubation Time:0-48 hours Result:Showed a transient accumulation of cells at G2/M after 12 h, then showed an accumulation at G0/G1 that peaked after 24 h.Decreased in the S phase cell in accompany with the increase in the G0/G1 phase.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    329227-30-7
  • Formula Weight
    309.67
  • Molecular Formula
    C11H8ClN5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 33.33 mg/mL (107.63 mM; Ultrasonic )
  • SMILES
    Oc1ccc(\C=N\Nc2cn[nH]c(=O)c2Cl)cc1[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.?
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