
L82
CAS No. 329227-30-7
L82( —— )
Catalog No. M35468 CAS No. 329227-30-7
L82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 61 | Get Quote |
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10MG | 100 | Get Quote |
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25MG | 181 | Get Quote |
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50MG | 288 | Get Quote |
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100MG | 447 | Get Quote |
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500MG | 972 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameL82
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NoteResearch use only, not for human use.
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Brief DescriptionL82 is a DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM) that is selective and non-competitive.L82 expresses anti-proliferative activity against breast cancer cells.
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DescriptionL82 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells.
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In VitroL82 (0-50 μM; 6 d) shows anti-proliferative activity to breast cancer cells.L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.Cell Proliferation Assay Cell Line:MCF10A, MCF7, HCT116, and HeLa cells Concentration:0-50 μM Incubation Time:6 days Result:Reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa and HCT116, in a concentration-dependent manner.Cell Cycle Analysis Cell Line:MCF7 cells Concentration:50 μM Incubation Time:0-48 hours Result:Showed a transient accumulation of cells at G2/M after 12 h, then showed an accumulation at G0/G1 that peaked after 24 h.Decreased in the S phase cell in accompany with the increase in the G0/G1 phase.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA
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Research Area——
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Indication——
Chemical Information
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CAS Number329227-30-7
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Formula Weight309.67
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Molecular FormulaC11H8ClN5O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 33.33 mg/mL (107.63 mM; Ultrasonic )
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SMILESOc1ccc(\C=N\Nc2cn[nH]c(=O)c2Cl)cc1[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.?
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