L524-0366

CAS No. 951612-19-4

L524-0366 ( [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone )

Catalog No. M22217 CAS No. 951612-19-4

L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 178 Get Quote
5MG 267 Get Quote
10MG 408 Get Quote
25MG 692 Get Quote
50MG 896 Get Quote
100MG 1305 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    L524-0366
  • Note
    Research use only, not for human use.
  • Brief Description
    L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
  • Description
    L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
  • Synonyms
    [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Fn14
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    951612-19-4
  • Formula Weight
    308.79
  • Molecular Formula
    C13H13ClN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.
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