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L524-0366

CAS No. 951612-19-4

L524-0366( [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone )

Catalog No. M22217 CAS No. 951612-19-4

L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 178 Get Quote
5MG 267 Get Quote
10MG 408 Get Quote
25MG 692 Get Quote
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Biological Information

  • Product Name
    L524-0366
  • Note
    Research use only, not for human use.
  • Brief Description
    L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
  • Description
    L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Fn14
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    951612-19-4
  • Formula Weight
    308.79
  • Molecular Formula
    C13H13ClN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.
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