L524-0366
CAS No. 951612-19-4
L524-0366 ( [1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone )
Catalog No. M22217 CAS No. 951612-19-4
L524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 178 | Get Quote |
|
5MG | 267 | Get Quote |
|
10MG | 408 | Get Quote |
|
25MG | 692 | Get Quote |
|
50MG | 896 | Get Quote |
|
100MG | 1305 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameL524-0366
-
NoteResearch use only, not for human use.
-
Brief DescriptionL524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling.
-
DescriptionL524-0366 is a TWEAK-Fn14 signaling cascade inhibitor.L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/-?fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
-
Synonyms[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone
-
PathwayOthers
-
TargetOther Targets
-
RecptorFn14
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number951612-19-4
-
Formula Weight308.79
-
Molecular FormulaC13H13ClN4OS
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(C1=CN(C2=CC=CC(Cl)=C2)N=N1)N3CCSCC3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Unudurthi S D , Nassal D M , Patel N J , et al. Fibroblast growth factor-inducible 14 mediates macrophage infiltration in heart to promote pressure overload-induced cardiac dysfunction[J]. Life ences, 2020, 247:117440.
molnova catalog
related products
-
DCU
Dicloralurea is a organic compound with molecular fomula C5H6Cl6N2O3.
-
Myomodulin
Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
-
4,2-Dihydroxy-4-meth...
(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.