L-Propargylglycine

CAS No. 23235-01-0

L-Propargylglycine ( (S)-Propargylglycine,(S)-alpha.Propargylglycine,Propargylglycine )

Catalog No. M22868 CAS No. 23235-01-0

L-Propargylglycine is an inhibitor of the enzyme.l-propargylglycine (LPG) irreversibly inhibited the enzyme from Crotalus adamanteus and Crotalus atrox in a dose- and time-dependent manner.?Inactivation was irreversible which was significantly protected by the substrate l-phenylalanine.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG 35 In Stock
500MG 88 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    L-Propargylglycine
  • Note
    Research use only, not for human use.
  • Brief Description
    L-Propargylglycine is an inhibitor of the enzyme.l-propargylglycine (LPG) irreversibly inhibited the enzyme from Crotalus adamanteus and Crotalus atrox in a dose- and time-dependent manner.?Inactivation was irreversible which was significantly protected by the substrate l-phenylalanine.?
  • Description
    L-Propargylglycine is an inhibitor of the enzyme.l-propargylglycine (LPG) irreversibly inhibited the enzyme from Crotalus adamanteus and Crotalus atrox in a dose- and time-dependent manner.?Inactivation was irreversible which was significantly protected by the substrate l-phenylalanine.?A Kitz-Wilson replot of the inhibition kinetics suggested formation of reversible enzyme-LPG complex, which occurred prior to modification and inactivation of the enzyme.?UV-visible and fluorescence spectra of the enzyme and the cofactor strongly suggested formation of covalent adduct between LPG and an active site residue of the enzyme.?A molecular modeling study revealed that the FAD-binding, substrate-binding and the helical domains are conserved in SV-LAAOs and both His223 and Arg322 are the important active site residues that are likely to get modified by LPG.
  • Synonyms
    (S)-Propargylglycine,(S)-alpha.Propargylglycine,Propargylglycine
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    23235-01-0
  • Formula Weight
    113.11
  • Molecular Formula
    C5H7NO2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble
  • SMILES
    C#CCC(C(=O)O)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Irreversible inactivation of snake venom l-amino acid oxidase by covalent modification during catalysis of l-propargylglycine
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