L-JNKI-1( —— )

Catalog No. M30052 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

L-JNKI-1
Note

Research use only, not for human use.
Brief Description

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies.
Description

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies. (In Vivo):L-JNKI-1 has been shown to effectively inhibit JNK activity in in vivo studies. It is shown that Ang II induces a dose-dependent pressor response, which was significantly attenuated by JNK inhibition. It is also found that 10 μM L-JNKI-1 decreases phosphorylated c-Jun by 98% and phosphorylated Elk-1 by 100%. L-JNKI-1 is able to across the blood-brain barrier and penetrate neurons of adult mice and P5 rats within 1 h after an intraperitoneal injection.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

JNK
Research Area

——
Indication

——

CAS Number

——
Formula Weight

3822.44
Molecular Formula

C164H286N66O40
Purity

>98% (HPLC)
Solubility

H2O : ≥ 100 mg/mL (26.16 mM)
SMILES

——
Chemical Name

Sequence:Asp-Gln-Ser-Arg-Pro-Val-Gln-Pro-Phe-Leu-Asn-Leu-Thr-Thr-Pro-Arg-Lys-Pro-Arg-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-NH2

Zhou MS, et al. Role of c-Jun N-terminal kinase in the regulation of vascular tone. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):78-83.

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