L-Clausenamide

Research use only, not for human use.

L-Clausenamide is an alkaloid extracted from the leaves of the yellow bark (Clausena lansium (Lour) skeels) and can be used to improve cognitive function.

(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels,and improves cognitive function in both normal physiological and pathological conditions.(-)Clausenamide inhibits β-amyloid (Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation of tau protein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD).

(-)Clausenamide (10 and 100 μM) reverses the overload in [Ca2+]i level stimulated by Aβ25-35, and reduces Aβ-mediated cell apoptosis in PC12 cells.(-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK, down-regulates the expression of P53 and cleaved Caspase-3 and the ratio of Bax/Bcl-2, in Aβ25-35-treated PC12 cells.

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Others

Other Targets

Microtubule Associated

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201529-58-0

297.35

C18H19NO3

>98% (HPLC)

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[C@@H](O)([C@]1([C@H]([C@H](O)C(=O)N1C)C2=CC=CC=C2)[H])C3=CC=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years