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L-783277
CAS No. 791807-02-8
L-783277( L 783277 | L783277 )
Catalog No. M15970 CAS No. 791807-02-8
A resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameL-783277
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NoteResearch use only, not for human use.
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Brief DescriptionA resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM.
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DescriptionA resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM.
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In Vitro——
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In Vivo——
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SynonymsL 783277 | L783277
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorTGFBR
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Research Area——
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Indication——
Chemical Information
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CAS Number791807-02-8
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Formula Weight364.39
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Molecular FormulaC19H24O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1CC=CC(=O)C(C(CCCC2=C(C(=CC(=C2)OC)O)C(=O)O1)O)O
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Chemical Name(3S,5Z,8S,9S)-3,4,9,10,11,12-Hexahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liniger M, et al. ACS Med Chem Lett. 2010 Oct 20;2(1):22-7.
2. Cho H, et al. J Med Chem. 2017 Feb 23;60(4):1495-1508.
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