L-685,458
CAS No. 292632-98-5
L-685,458 ( L685458; L-685458; L 685458 )
Catalog No. M18379 CAS No. 292632-98-5
L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 335 | In Stock |
|
10MG | 520 | In Stock |
|
25MG | 840 | In Stock |
|
50MG | 1143 | In Stock |
|
100MG | 1521 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameL-685,458
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NoteResearch use only, not for human use.
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Brief DescriptionL-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
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DescriptionL685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
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SynonymsL685458; L-685458; L 685458
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PathwayOthers
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TargetOther Targets
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Recptorγ secretase
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number292632-98-5
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Formula Weight672.85
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Molecular FormulaC39H52N4O6
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Purity98%
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SolubilityDMSO : ≥ 31 mg/mL; 46.07 mM
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SMILESCC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
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Chemical Nametert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shearman M S, Beher D, Clarke E E, et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity[J]. Biochemistry, 2000, 39(30): 8698-8704.
molnova catalog
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