L-685,458

Research use only, not for human use.

L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.

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Animal Model:NOD-SCID Mouse Hepatoma Model Dosage:5 mg/kg Administration:Percutaneous administration; 5 mg/kg; 2 weeks Result:Exhibited anti-tumor activities in vivo.

L685458 | L-685458 | L 685458

Others

Other Targets

γ secretase

Neurological Disease

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292632-98-5

672.85

C39H52N4O6

>98% (HPLC)

DMSO : ≥ 31 mg/mL; 46.07 mM

CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.

(-20℃)

With Ice Pack

≥ 2 years