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L-685,458

CAS No. 292632-98-5

L-685,458( L685458 | L-685458 | L 685458 )

Catalog No. M18379 CAS No. 292632-98-5

L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    L-685,458
  • Note
    Research use only, not for human use.
  • Brief Description
    L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
  • Description
    L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.
  • In Vitro
    ——
  • In Vivo
    Animal Model:NOD-SCID Mouse Hepatoma Model Dosage:5 mg/kg Administration:Percutaneous administration; 5 mg/kg; 2 weeks Result:Exhibited anti-tumor activities in vivo.
  • Synonyms
    L685458 | L-685458 | L 685458
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    γ secretase
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    292632-98-5
  • Formula Weight
    672.85
  • Molecular Formula
    C39H52N4O6
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 31 mg/mL; 46.07 mM
  • SMILES
    CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
  • Chemical Name
    tert-butyl ((2S,3R,5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shearman M S, Beher D, Clarke E E, et al. L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity[J]. Biochemistry, 2000, 39(30): 8698-8704.
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