KYP-2047
CAS No. 796874-99-2
KYP-2047 ( —— )
Catalog No. M22395 CAS No. 796874-99-2
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 84 | In Stock |
|
5MG | 120 | In Stock |
|
10MG | 181 | In Stock |
|
25MG | 327 | In Stock |
|
50MG | 489 | In Stock |
|
100MG | 705 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameKYP-2047
-
NoteResearch use only, not for human use.
-
Brief DescriptionKYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
-
DescriptionKYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorProlyl oligopeptidase(pop)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number796874-99-2
-
Formula Weight339.44
-
Molecular FormulaC20H25N3O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESO=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. T T My?h?nen 1 , M J Hannula, R Van Elzen,et al.A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.Br J Pharmacol. 2012 Jun;166(3):1097-113.
molnova catalog
related products
-
Quercetin 3-O-beta-(...
Quercetin 3-O-β-D-(6''-p-coumaroyl)glucopyranosyl(1→2)-α-L-rhamnopyranoside is a compound extracted from the leaves of Ginkgo biloba.
-
METHYL UNDECANOATE
Methyl undecanoate is an internal standard in gas-liquid chromatogram.
-
phosphorylcholine
Phosphorylcholine is an antigenic cell-surface component found on many commensal and pathogenic bacteria that reside in the upper airway.