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KYP-2047
CAS No. 796874-99-2
KYP-2047 ( —— )
Catalog No. M22395 CAS No. 796874-99-2
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 84 | In Stock |
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| 5MG | 120 | In Stock |
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| 10MG | 181 | In Stock |
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| 25MG | 327 | In Stock |
|
| 50MG | 489 | In Stock |
|
| 100MG | 705 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameKYP-2047
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NoteResearch use only, not for human use.
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Brief DescriptionKYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
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DescriptionKYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.?In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorProlyl oligopeptidase(pop)
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Research Area——
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Indication——
Chemical Information
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CAS Number796874-99-2
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Formula Weight339.44
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Molecular FormulaC20H25N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. T T My?h?nen 1 , M J Hannula, R Van Elzen,et al.A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease.Br J Pharmacol. 2012 Jun;166(3):1097-113.
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