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KYN-101
CAS No. 2247950-73-6
KYN-101( —— )
Catalog No. M36421 CAS No. 2247950-73-6
KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 93 | Get Quote |
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| 5MG | 140 | Get Quote |
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| 10MG | 217 | Get Quote |
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| 25MG | 394 | Get Quote |
|
| 50MG | 609 | Get Quote |
|
| 100MG | 894 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameKYN-101
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NoteResearch use only, not for human use.
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Brief DescriptionKYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.
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DescriptionKYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.
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In Vitro——
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In VivoAnimal Model:6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)Dosage:10 mg/kg Administration:P.o.; daily for 12 days Result:Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAhR
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RecptorAhR
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Research Area——
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Indication——
Chemical Information
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CAS Number2247950-73-6
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Formula Weight386.43
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Molecular FormulaC22H19FN6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (258.79 mM; Ultrasonic )
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SMILESFC1=CN=CC(=C1)C2=NC3=C(C=NN3C(=C2)NCCC4=CNC=5C=CC=CC54)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Campesato LF, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020 Aug 11;11(1):4011.?
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