KYN-101

CAS No. 2247950-73-6

KYN-101( —— )

Catalog No. M36421 CAS No. 2247950-73-6

KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 93 Get Quote
5MG 140 Get Quote
10MG 217 Get Quote
25MG 394 Get Quote
50MG 609 Get Quote
100MG 894 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    KYN-101
  • Note
    Research use only, not for human use.
  • Brief Description
    KYN-101 is an orally active and selective aryl hydrocarbon receptor (AHR) inhibitor with anticancer activity.
  • Description
    KYN-101 is a potent, selective and orally active AHR inhibitor. KYN-101 decreases the CYP1A1 mRNA expression. KYN-101 shows anti-cancer activity.
  • In Vitro
    ——
  • In Vivo
    Animal Model:6-8 weeks, C57BL/6J mice (B16IDO tumor-bearing mice)Dosage:10 mg/kg Administration:P.o.; daily for 12 days Result:Reduced tumor growth in B16IDO tumor-bearing mice and combination of KYN-101 and anti-PD-1 led to improved tumor growth delay and extended survival in CT26 models.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2247950-73-6
  • Formula Weight
    386.43
  • Molecular Formula
    C22H19FN6
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (258.79 mM; Ultrasonic )
  • SMILES
    FC1=CN=CC(=C1)C2=NC3=C(C=NN3C(=C2)NCCC4=CNC=5C=CC=CC54)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Campesato LF, et al. Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine. Nat Commun. 2020 Aug 11;11(1):4011.?
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