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KY-05009
CAS No. 1228280-29-2
KY-05009( —— )
Catalog No. M26273 CAS No. 1228280-29-2
KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 40 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 111 | In Stock |
|
| 25MG | 267 | In Stock |
|
| 50MG | 389 | In Stock |
|
| 100MG | 560 | In Stock |
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| 500MG | 1152 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKY-05009
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NoteResearch use only, not for human use.
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Brief DescriptionKY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells.
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DescriptionKY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the protein expression of TNIK and transcriptional activity of Wnt target genes and induces apoptosis in cancer cells. KY-05009 exerts anti-cancer activity.?KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor (Ki = 100 nM).?(In Vitro):KY-05009 (1-3 μM; 48-72 hours; RPMI8226 cells) treatment induces caspase-dependent apoptosis in RPMI8226 cells in a dose-dependent manner. KY-05009 (3 μM; 1 hour; RPMI8226 cells) treatment suppresses the transcriptional activity of Wnt signaling-related genes, including TNIK, CTNNB1, TCF7, and TCF4. KY-05009 (3 μM; 9 hours; RPMI8226 cells) treatment inhibits the IL-6-induced interaction between TCF4 and β-catenin and the phosphorylation of TCF4.KY-05009 (0.1-30 μM;?24 hours;?RPMI8226 cells) treatment inhibits the proliferation of RPMI8226 cells in a dose-dependent manner.
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In VitroCell Proliferation Assay Cell Line:RPMI8226 cells Concentration:0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, 30 μM Incubation Time:24 hours Result:Inhibited the proliferation of RPMI8226 cells.Apoptosis Analysis Cell Line:RPMI8226 cells Concentration:1 μM, 3 μM, 10 μM Incubation Time:48 hours, 72 hours Result:Induced the binding of fluorescent Annexin V and 7-amino-actinomycin D (7-AAD) uptake.RT-PCR Cell Line:RPMI8226 cells Concentration:3 μM Incubation Time:1 hour Result:Suppressed the transcriptional activity of Wnt signaling-related genes, including TNIK, CTNNB1, TCF7, and TCF4.Western Blot Analysis Cell Line:RPMI8226 cells Concentration:3 μM Incubation Time:9 hours Result:The IL-6-induced interaction between TCF4 and β-catenin and the phosphorylation of TCF4 were inhibited.
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In Vivo——
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Synonyms——
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1228280-29-2
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Formula Weight352.41
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Molecular FormulaC18H16N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (236.46 mM)
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SMILESCc1ccc(cc1)C(=O)Nc1sc(Nc2ccccc2)nc1C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Groome NP. Superiority of ABTS over Trinder reagent as chromogen in highly sensitive peroxidase assays for enzyme linked immunoadsorbent assay. J Clin Chem Clin Biochem. 1980 Jun;18(6):345-9.
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