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KT-5720

CAS No. 108068-98-0

KT-5720( KT5720 )

Catalog No. M10323 CAS No. 108068-98-0

KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KT-5720
  • Note
    Research use only, not for human use.
  • Brief Description
    KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM).
  • Description
    KT-5720 is a highly specific PKA (cAMP-dependent protein kinase) inhibitor with Ki of 60 nM displays little to no activity for MLCK, cGPK, and PKC (Ki>2 uM); reversibly arrests human skin fibroblasts in the G1 phase.
  • In Vitro
    ——
  • In Vivo
    Animal Model:MDR1 transgenic mice model.Dosage:5 mg/kg Administration:Intraperitoneal injection; single daily for 8 days Result:Exhibited the leukopenia induced by daunorubicin in the MDR mice was equivalent to that measured in non-MDR mice treated with daunorubicin alone.
  • Synonyms
    KT5720
  • Pathway
    Apoptosis
  • Target
    PKA
  • Recptor
    PKA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    108068-98-0
  • Formula Weight
    537.605
  • Molecular Formula
    C32H31N3O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Methanol :5 mg/mL (9.30 mM)
  • SMILES
    O=C([C@](C[C@@](O1)([H])N2C3=CC=CC=C43)(O)[C@]1(C)N5C6=CC=CC=C6C7=C5C2=C4C8=C7CNC8=O)OCCCCCC
  • Chemical Name
    9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, hexyl ester, (9R,10S,12S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gadbois DM, et al. Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8626-30. 2. Feng H, et al. Neuro Oncol. 2015 Jun;17(6):832-42. 3. Ott SR, et al. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):E381-7.
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