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KRM-II-81
CAS No. 2014348-91-3
KRM-II-81( KRM-II-81 | KRM-II 81 | KRM-II81 )
Catalog No. M13139 CAS No. 2014348-91-3
KRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1143 | Get Quote |
|
| 50MG | 2322 | Get Quote |
|
| 100MG | 3060 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameKRM-II-81
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NoteResearch use only, not for human use.
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Brief DescriptionKRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors.
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DescriptionKRM-II-81 is a potent, selective α1/α2/α3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for α1β3γ2, negligible efficacy at α4/α5/α6 GABAA receptors; shows α2 and α3-subtypes being 17- and 28-fold more potent than α1 subtypes in HEK-293T cells expressing GABAA receptors with different α subunits.
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In Vitro——
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In Vivo——
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SynonymsKRM-II-81 | KRM-II 81 | KRM-II81
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PathwayMembrane Transporter/Ion Channel
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TargetGAT
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RecptorGAT
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Research Area——
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Indication——
Chemical Information
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CAS Number2014348-91-3
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Formula Weight351.369
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Molecular FormulaC21H13N5O
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Purity>98% (HPLC)
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Solubility——
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SMILESC#CC1=CC=C(N2C(CN=C3C4=NC=CC=C4)=C(C5=CN=CO5)N=C2)C3=C1
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Chemical Name5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Poe MM, et al. J Med Chem. 2016 Dec 8;59(23):10800-10806.
2. Lewter LA, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1305-1312.
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