KO-947 ( KO 947;KO947 )

Catalog No. M12583 CAS No. 1695533-89-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KO-947
Note

Research use only, not for human use.
Brief Description

KO-947 is a potent and selective inhibitor of ERK1/2 kinase in biochemical, cellular and in vivo antitumor activity assays.
Description

KO-947 is a potent and selective inhibitor of ERK1/2 kinase in biochemical, cellular and in vivo antitumor activity assays; blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling, including mutations in BRAF, NRAS or KRAS, at low nanomolar concentrations.Solid Tumors Phase 1 Clinical
Synonyms

KO 947;KO947
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1695533-89-1
Formula Weight

355.40
Molecular Formula

C21H17N5O
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL 175.86 mM
SMILES

O=C1NC2=CC(NN=C3C4=CC=NC=C4)=C3C=C2CN1CC5=CC=CC=C5
Chemical Name

6-benzyl-3-(pyridin-4-yl)-1,5,6,8-tetrahydro-7H-pyrazolo[4,3-g]quinazolin-7-one