KL-11743

Research use only, not for human use.

KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.

KL-11743 specifically blocks glucose metabolism, triggering an acute collapse in NADH pools and a striking accumulation of aspartate, indicating a dramatic shift toward oxidative phosphorylation in the mitochondria.(In Vitro):Patient-derived xenograft models of succinate dehydrogenase A (SDHA)-deficient cancers are specifically sensitive to KL-11743, providing direct evidence that TCA cycle-mutant tumors are vulnerable to GLUT inhibitors in vivo.

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Others

Other Targets

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1369452-53-8

522.6

C30H30N6O3

>98% (HPLC)

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CCOc1ccc2nc(nc(Nc3ccc(cc3)-c3cn[nH]c3)c2c1)-c1cccc(OCC(=O)NC(C)C)c1

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(-20℃)

With Ice Pack

≥ 2 years